Mexico, the powerhouse of this region, has become an industrialized nation with strong development in the North, but uprisings in the South and conflicts with Guatemala. Following decades of civil war, small nations such as Honduras, El Salvador and Panama re-emerged from anarchy and slowly joined the world economy by supplying pristine eco-tourist destinations and low-wage information-processing centres for Mexican informatics combines.

Mexico is a strong nationalist democracy whose patriotic ardour is exceeded only by its political infighting. Relations with the United States are - as ever - lukewarm and ambiguous. While the Mexican government promotes economic ties with America, it vigorously attacks any American paternalism or attempts to weaken its ties to Mexican-Americans in SurCal, New Mexico and Texas. Those states are mainly populated by Hispanics and as such maintain close ties with their home country. The ruling Justitia Party relies on conservative-minded Hispanic votes to maintain its monolithic power even while it reviles anything that smacks of multiculturalism. Nevertheless the economic power of wealthy Spanish-speakers in the Southern USA exerts enough pull to moderate American colonial policy in the region. For the past two decades America has allowed Mexico to exert influence over the Central American region, with the result that countries such as Panama and El Salvador are filled with Mexican soldiers enforcing tribal peace treaties. Strangely enough, the north Mexican states of Nuevo Leon, Sonora, Baja California, and Chihuahua consider themselves more American than Mexican, and fiercely resist any 'meddling' from politicians in Mexico City. A strong revival of old Aztec mythology and architecture has been in evidence in the southern states, and helps to provide Mexicans with a unique cultural climate wherein they can feel secure from the all-pervasive American globoculture. With the introduction of pharmas after the New Mutation, Mexico's powerful drug cartels were shattered by waves of sting operations and the introduction of legal drug-processing centers. Most of the black market moved into open business while the corruption moved into the webworks, where turbohackers infiltrated the pharma databases to redirect shipments to blanks.

The New Mutation took a horrific toll in Centram, especially weakening the Native Indian communities. The upside of this biological disaster was that the countless uprisings which had kept smoldering into the Tens were extinguished as rebels acquiesced to the necessity of working with governments to temper the plagues. Today Central America is united in an economic confederation called Centram, but still consists of small and suspicious nation-states. With Mexican peacekeeping forces stationed throughout the region, the potential for confrontation is growing daily.

Centram's most successful nation is probably Costa Rica, which has focused on tourism and informatics-processing for large Mexican and American combines. Three-quarters of the population speak English, and the education system is the envy of other Latinos. Costa Rica plays host to several datahavens and Atlantean high-grade Vaults.

Playing second-best and fairly high on the list of economic development is Cuba, once a crippled foe of the United States and today probably its most important economic possession after coastal China. Following the death of old-time Communist leader Fidel Castro the nation was plunged into a bitter succession battle in which the progressive Gauto Mellende emerged victorious. Mellende's rapprochement with the still-hostile American government brought a lifting of sanctions and eventual free-trade in the 20s. Cuba's economy took off after American corporations started a massive investment drive and Cuba's previous investment in excellent education and social equality finally paid off. Following in the footsteps of Puerto Rico, Cuba was eventually granted associate status with the US and decided for closer economic integration with the 'mainland'. Still, Cubans' fierce nationalism has caused trouble at home among disaffected youth who resent Washington's heavy and paternalistic hand. As a center of growth in the Caribbean, Cuba has attracted many Black migrants from the region and exerts influence over the politics of South Florida, creating the Sun Zone centered on Miami.

Guatemala was wracked by violence during the 2010s are Indians massacred whites in rural areas in retaliation for a campaign of 'quiet eradication'. This carnage culminated in the release of a terrible pathogen in Guatemala City in 2012 which killed most of the city's (white) inhabitants and pushed Mexico into invading the country two weeks later. Gautemala has since gained autonomy within Mexico, but rebel groups continue to use forbidden parasites and virii for terrorist purposes.